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Bendamustine 100 is a remedy whose active substance has a cytostatic effect and antitumor activity. Therefore, Bendamustine is used as a chemotherapeutic agent for fighting some types of cancer. This article describes more detailed information on the mechanism of action of the remedy, the possible reactions of the body to the substance, the treatment scheme, which is intended for familiarization and is not an instruction for self-treatment.
Description and Purpose of Bendamustine 100.
A group of substances called alkylating has the ability to introduce monovalent alkyl radicals (fatty hydrocarbons) into molecules of various organic compounds, which ultimately results in the blocking of all stages of the transfer of genetic information within cells. Both DNA replication and protein synthesis are blocked. And this, in turn, leads to the death of malignant neoplasms. The described group of substances includes Bendamustine, which is part of the remedy Bendamustine 100.
The main indications for the use of Bendamustine 100 are the following diseases:
Non-Hodgkin’s lymphoma (other and unspecified types);
Malignant plasma cell neoplasms;
Chronic lymphocytic leukemia.
The mechanism of action of Bendamustine 100 justifies its use and high effectiveness as a chemotherapeutic agent. It is very dangerous with uncontrolled treatment, so you can buy Bendamustine only by prescription. It is not sold in conventional pharmacies, except for large companies involved in the supply of medicines.
Useful properties of Bendamustine 100.
Fighting cancer cells
Bendamustine can be briefly described in the following words: cytostatic, chemotherapeutic, antitumor, alkylating. This short list of adjectives can give a superficial understanding of the benefits of this remedy. In order to better understand the useful properties of Bendamustine, it is necessary to study the mechanism of its action in more detail.
The remedy has high dissociation ability, so it quickly decays into constituent components upon ingestion. Due to this process, a high biological activity of the active substance is manifested.
The positively charged radicals formed as a result of dissociation are highly reactive, they attack nucleic acids, proteins, nucleotides and amino acids, resulting in nucleophilic substitution. This type of substitution means the covalent attachment of an alkyl group to biomacromolecules with replacement of hydrogen atoms.
Contraindications for the using of Bendamustine.
Each remedy that exerts a cytostatic effect has contraindications common to the group of cytostatics. These include:
Hypersensitivity to the active ingredient or auxiliary components;
The presence of generalized infections;
Violation of the blood composition (hypoplastic anemia).