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Ribomustin 100 mg according to the information specified in the instructions to the remedy is an antitumor cytotoxic remedy with an alkylating type of action. It is synthesized for bis-beta-chloroethylamine. As indicated in the description of the active substance, the alkylating effect of the remedy occurs at the DNA level. The active substance is bendamustine. The remedy is metabolized in the liver and excreted by the kidneys, as well as with bile.
The appointment and calculation of the dosage of the remedy is made by a specialist with sufficient experience in the use of chemotherapy in a specialized hospital. Ribomustin is indicated for use in chronic lymphocytic leukemia and with non-Hodgkin’s lymphomas progressing against the background of treatment with other remedies. The remedy is administered parent rally, intravenously drip. Calculation of the dose is based on the measurement of the patient’s body area. With leukemia, the remedy is administered on the first and second days with a cyclicity of 28 days. During the recovery period, laboratory monitoring of hematological parameters is performed. When the level of erythrocyte and leukocyte content is within normal limits, the number of cycles of administration can reach six. In the case of diagnosis of non-Hodgkin’s lymphoma, the frequency of administration of the remedy increases (on the first and second days of the 21-day cycle), and the number of infusions can reach 8. The working solution in the proper dosage is prepared immediately before using.
Correction of dosage according to sex, age and race is not required. Most side effects, in addition to violations of hemopoiesis, are of general clinical nature and require symptomatic treatment. Contraindications to the using of Ribomustin are hepatic and renal failure, surgical interventions less than 3 days before the start of therapy, individual hypersensitivity to the active substance of the remedy. The remedy is not used in pediatric practice, nor is it prescribed for pregnant women and nursing mothers. There is no specific antidote for overdose. The remedy does not require special storage conditions and is dispensed from pharmacies according to the prescription.