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The drug is available in the form of pills for oral reception. The pills are coated with a film coating. The drug is an anticoagulant of direct action. Pharmacological effects include inhibition of FXa activity. The result of this impact is the change in the values of indicators of blood coagulation system that extends prothrombin time. The changes in such indicators in the course of therapy are individual for each patient. The intensity and percentage change of anti-FXa activity is directly proportional to the increase in the concentration of apixaban in the patient’s blood plasma.

Indications for use

The use of Eliquis is recommended by specialists for the prevention of thromboembolism, in patients who have undergone planned endoprosthesis of hip or knee. The use of the drug for such patients has only positive feedback.
Method of reception and dosage
Pills of Eliquis are taken orally. The drug is prescribed after the planned endoprosthesis at the dosage of 2.5 mg twice a day and the reception starts in twelve hours after the intervention. The duration of treatment is thirty-eight days for hip replacement and fourteen days for knee replacement.
If you suffer atrial fibrillation, you should take 5 mg of the drug twice a day. If your weight is less than 60 kg and you are less than 80 years old — you should take 2.5 mg twice a day.

Drug contradictions

It is not recommended to use the drug in the treatment of patients who have the following contraindications:
clinically significant active bleeding
severe violations of liver
hypersensitivity to the components or the main active ingredient of the drug
liver diseases, which are accompanied by significant disturbances in blood clotting processes, as well as a significant risk of bleeding
simultaneous use of drugs that are associated with the development of bleeding
It is also not recommended for patients under the age of 18 years.
If you want to prevent the manifestation of side effects that can lead to serious consequences, the appointment of a course of treatment and dosage of the drug should be performed only by a treating specialist who already knows the history of the disease and the characteristics of the patient’s body.

Side effects

Patients, who take this drug, may experience thrombocytopenia, including a decrease in the number of platelets in the blood. More rare side effects are hemorrhage into the tissue of the eyeballs, alternative hypotension, urethral or vaginal bleeding.


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