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Kinase class enzymes, which include protein tyrosine kinase, provide molecular transfer of phosphates and metabolic processes for glucose, help the body synthesize the various compounds necessary for life, and also alter certain proteins. By regulating metabolism, such enzymes also help to transmit signals within cells, plus they affect cell division, their growth and programmed death (so-called apoptosis). However, the protein tyrosine kinase that appears as a result of the “Philadelphia” mutation, also known as tyrosine-specific protein kinase, provokes abnormal production of leukocyte-granulocytes; when their colonies become too large, and the amount in the blood goes high, the oncological disease is diagnosed with leukemia.
Niraparib inhibits the proliferation of granulocytes and triggers their apoptosis, acting selectively – only on abnormal sites. This selectivity is achieved by the fact that the remedy affects precisely the cells with the “Philadelphia chromosome” producing protein tyrosine kinase and inhibits the production of an unwanted enzyme.
Indications for using of Niraparib.
The medicine is prescribed when:
diagnosed in the patient “Philadelphia chromosome”, when it is not a bone marrow transplant;
treatment of chronic myeloid leukemia with the presence of the “Philadelphia chromosome” in the body (especially if a remedy such as interferon-alpha did not help);
treatment of leukemia, leukemia with the presence of the “Philadelphia chromosome” in the body – in combination with chemotherapy and independently;
treatment of eosinophilic leukemia;
mutation of the gene responsible for the production of platelet-derived growth factor;
treatment of certain types of tumors of the stomach and intestines;
therapy of dermatofibrosarcoma, not subject to prompt removal.
Method of application of Niraparib.
Despite the easy-to-use form of the remedy, Niraparib cannot be used without oncologist control. The medication is taken concomitantly with food, drinking heavily (a lack of liquid in this case can provoke gastrointestinal complications). If there are problems with swallowing the tablet, it should be poured with water and wait for complete dissolution.
Depending on the stage in which the disease is located and what type it is, doses of 100, 200 and 300 milligrams daily are used. Dosage of 200 or 300 milligrams is taken once every 24 hours, 400 milligrams dosage is divided into two doses per day.
The dose is increased if the patient has no complaints of severe side effects from Niraparib and there is an insufficient effect of the remedy, as can be seen from regular analyzes. Niraparib therapy is considered safe, in which the disease does not progress, and the side effects are not pronounced.