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Pirfenidone 200mg is available in the form of white gelatin capsules for oral reception. Each capsule consists of 200 mg of the active substance (Pirfenidone). It is a white powder that does not have hygroscopic properties and dissolves well in alcohol, acetone, chloroform.
The active substance- pirfenidon has an anti-inflammatory effect, penetrating into the body. It prevents the spread of cancer cells by blocking the growth factor of fibroblasts, platelets, controls the production of fibrous proteins and cytokines.
The maximum content of the drug in blood plasma is observed from half an hour to 4 hours after taking a dose of the drug. Pirfenidone is metabolized in the liver and forms several compounds that are not pharmacologically active. The medicine is excreted in the urine in three hours after reception.
Clinical studies were conducted on two groups of patients. One group was taking Pirfenidone, and the other – a placebo. After the course of treatment, 80% of patients of the first group felt the significant improvement, 15% were forced to interrupt the treatment, due to strong side effects from the gastrointestinal tract. In total, the result was positive and the tolerance was good.
Indications for use
Pirfenidone 200mg is used in the treatment of idiopathic pulmonary fibrosis. It has established itself as a wonderful tool that improves the condition of patients and prolongs their life. The most stable result is achieved when used in combination with other drugs prescribed by the attending physician.
Dosage and reception
Pirfenidone 200mg is taken orally at the dosage of three capsules three times a day. In total, the daily dose is 2403 mg, if a capsule contains 200 mg of the drug. The course of treatment lasts for two weeks, during which the maximum daily dose cannot be exceeded. After a fourteen-day course, you can take a break of 2 weeks and start taking the drug again.
If you notice the emergence of reactions from the gastrointestinal tract and photosensitivity, it is recommended to reduce the dose; the same rule applies to the increase of level of bilirubin and liver enzymes. If the dose reduction hasn’t given the desired result, the treatment must be discontinued. All prescriptions and dosage changes take place under the guidance of an experienced doctor. Dose adjustment is not required for elderly people, patients with hepatic and renal insufficiency.