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Mechanism of action
The activity of dasatinib is manifested in cellular models of leukemia. This occurs both with respect to sensitive cells and against imatinib-resistant cells. Dasatinib helps to overcome the resistance of cells to imatinib associated with overexpression of BCR-ABL, BCR-ABL kinase domain mutations, activation of alternative mechanisms inducing kinases of the SRC family (LYN, NSC), as well as overexpression of the multiple drug resistance gene.
Protocol for the application of Sprycel 100mg
The remedy Sprycel 100mg (dasatinib) is taken orally, regardless of food intake.
At the initial stage of treatment it is recommended to take Sprycel 100mg once a day in case of chronic myeloid leukemia. In all other cases – 140 mg once a day.
In consequence, the dose of the remedy can be increased to 140 mg once a day in the case of chronic myeloid leukemia and up to 180 mg once a day in all other cases. The increase in dose is justified in the absence of hematological and cytogenetic reactions due to the taking of initial doses.
Efficiency of taking
The remedy Sprycel 100mg (dasatinib) has been successfully used in the treatment of chronic myelogenous leukemia, which is in the chronic phase and was detected for the first time.
Also, the remedy is successfully used in the treatment of chronic myelogenous leukemia in the chronic phase, the phase of acceleration or the phase of the myeloid or lymphoid blast crisis, with the condition of resistance or intolerance to previous therapy, including imatinib.
Treatment with the remedy Sprycel 100mg is also justified in the case of acute lymphoblastic leukemia with a positive Philadelphia chromosome, provided that the previous therapy is resistant or intolerant.
Contraindications of the remedy
Hypersensitivity to dasatinib or other components that make up the remedy. Also, do not take the remedy during pregnancy and lactation. Remedies are not allowed for children under the age of 18 years.
Side effects of Sprycel 100mg
Most of the side effects of the remedy Sprycel 100mg are temporary and disappear with prolonged treatment.
The most common side effects are: infections (including upper respiratory tract infections and herpetic infections), pneumonia, enterocolitis, headache, bleeding, pleural effusion, shortness of breath, diarrhea, nausea, vomiting, abdominal pain, skin rash, musculo-skeletal pain, fluid retention, swelling of the subcutaneous tissue, edema of the tongue, lips, conjunctivitis, fatigue and fever.