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A medicinal product that manufactured in the form of a concentrate for the preparation of a solution for infusions, a ready solution for infusions and lyophilizate for the preparing solutions for infusions. The main active substance of the remedy is Zoledronic acid. Pharmacological action of the remedy is to inhibit bone resorption. The remedy refers to highly effective bisphosphonates, which have a selective effect on bone tissue. In the process of taking, the active substance of the remedy suppresses the activity of osteoclasts, while not adversely affecting the formation, mineralization and mechanical properties of the patient’s bone tissue. This selective effect on bone tissue is based on the high similarity of bisphosphonates with mineralized bone tissue. Although the exact mechanism by which the inhibition of osteoclast activity is realized, remains unexplored and unknown at this time.
The using of the remedy allows achieving a reduction in tumors, ensuring the effectiveness of treatment for bone metastases. Clinical studies have established that the acid is capable of inhibiting proliferation and inducing apoptosis of cells, thereby exerting an antitumor effect on breast cancer cells, and also reducing the risk of metastasis.
Indications for using Zoledronic Acid.
The instruction recommends the using of the remedy in osteosclerotic and mixed bone metastases of solid tumors. Best reviews of Zoledronic acid was obtained when used in the treatment of patients suffering from hypercalcemia caused by a malignant tumor, postmenopausal osteoporosis, in the prevention of osteoporotic fractures in women and men, as well as in the treatment of Paget’s disease.
Contraindications of Zoledronic Acid.
It is not recommended to use the remedy if the patient has the following contraindications:
hypersensitivity to the active substance;
children and adolescence;
lactation and pregnancy.
Side effects of Zoledronic Acid.
In case of violation of the rules for the using of this remedy, the following side effects may occur: