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Atripla is used as a monotherapy or in combination with other antiretroviral agents for the treatment of infection caused by the human immunodeficiency virus type I (HIV-1) in adults with virological resistance for HIV RNA levels, provided antiretroviral therapy for more three months.
Before starting to take antiretroviral therapy in the form of Atripla, patients should not have an unsuccessful outcome from prior therapy with other drugs against HIV infection. If previously there has been cases of unsuccessful therapy, then there are likely mutations of the virus and the patient must necessarily be checked for resistance to its generation of the virus to each of the three components of Atripla (ie pass the test for resistance to efavirenz, emtricitabine and tenofovir). If there is significant resistance to any of the three components of Atripla, then the use of this therapy would be impractical. In any case, the therapy should be appointed by a doctor with experience in the treatment of HIV infection.
The recommended dosage for adults is 1 tablet of Atripla orally once a day. The tablet should be swallowed whole, without chewing and while washing it with water. The atrial is recommended to be taken on an empty stomach, as eating often leads to an increase in the concentration of efavirenz and can cause frequent negative reactions of the body.
If you follow the recommendations for taking the drug Atripla on an empty stomach, the expected concentration of tenofovir should be no more than 35% compared with taking with the use of tenofovir dizoproxil fumarate, combining them with food individually. For HIV+ patients with undetectable viral load, it is assumed that this clinical indicator may not correspond to a notable decrease. Also for patients taking Atripla, a decrease in the pharmacokinetic effect is characteristic, which is confirmed in clinical conditions.
Since Atripla is a combined drug and the dosage for the patient is strictly fixed, there are not many side effects. Side effects are often associated with the individual antiretroviral agents listed above. The most common manifestations of such side effects as diarrhea, dizziness, nausea, headache, depressed state, depression, prolonged insomnia, disturbed sleep, chronic lack of sleep.