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The description of Bosentan 62, 5 mg

The drug contains Bosentan, which blocks a natural hormone called endothelin 1 (ET-1), causing blood thinning. Therefore, Bosentan causes vasodilation and belongs to a group of drugs called “endothelin receptor blockers”.
The medicine is used to treat pulmonary arterial hypertension (PAH).
It is used for the treatment of patients with the 3rd class of PAH to improve the ability to perform physical activity and symptoms.
Some improvements were also demonstrated in patients with the 2nd class of PAH.

PAH, which is treated with this drug, can be:

primary (with undetermined cause or inheritance),
caused by scleroderma (also called systemic sclerosis, a disease associated with an unusual growth of connective tissue that supports the skin and other organs)
caused by congenital heart defects with abnormal cardiac connections, causing an unusual flow of blood to the heart and lungs.
It is also used to treat ulcers (sores on arms and legs) in adult patients with a disease called scleroderma. Bosentan reduces the number of new digital ulcers of hands and feet.

Dosage and dosage schedules

Pulmonary arterial hypertension
Adults: the initial dose is 62.5 mg twice a day for 4 weeks.
Maintenance dose is 125 mg twice a day.
Children 1 year and older: the initial and maintenance dose is 2 mg / kg twice a day.
Systemic sclerosis with persistent peptic ulcer disease
Adults: the initial dose is 62.5 mg twice a day for 4 weeks. Maintenance dose is 125 mg twice a day.
The drug is contraindicated during pregnancy.
Women of childbearing age require a reliable method of contraception. During the use of the drug hormonal contraception can be temporarily reduced, so it is recommended to use as a barrier method of contraception.
The drug can reduce the number of sperm, which can affect the baby’s ability.
Breastfeeding is not recommended during treatment with Bosentan.
The drug is contraindicated to patients with moderate or severe hepatic insufficiency.
The drug can cause hypotension with symptoms such as dizziness, blurred vision, which can affect the ability to drive and use machines.


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