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Indications for taking
Kaletra is used in the combined treatment of adults and children older than 3 years with HIV infection.
Mode of application.
Kaletra tablets are for oral taking. At reception it is necessary to preserve the integrity of the shell. Kaletra tablets are taking regardless of food.
Dosage for Adult Patients:
Adult patients usually receive 4 tablets of Kaletra twice a day.
An alternative scheme is to take 8 tablets of Kaletra once a day. This scheme can be recommended only to patients who have not more than 3 mutations, which are associated with the mechanisms of development of resistance to lopinavir.
If omeprazole or ranitidine is used in complex therapy, correction of the dose of Kaletra tablets is not required.
If the patient is prescribed a complex therapy using efavirenz, amprenavir, nevirapine or nelfinavir (with a suspected low sensitivity to lopinavir, including if the patient has previously received antiretroviral therapy), the dose of Kaletra is increased to 5 tablets twice a day.
Dosage for children:
Adult doses of the preparation Kaletra (4 tablets twice a day) can be given to patients without combined therapy with nelfinavir, efavirenz, nevirapine or amprenavir in case the body weight and body surface area is more than 35 kg and 1.4 m2.
The dose of Kaletra tablets for children weighing up to 35 kg and body surface area (BSA) of 0.6-1.4 m2 is determined individually:
Children under the age of 3 years, as well as with BSA less than 0.6 m2 Kaletra tablets are not prescribed.
Side effects of the remedy
In adult patients, the development of diarrhea was recorded most often. Also in adults such undesirable phenomena were recorded.
Urinary system: nephrolithiasis, hematuria, changes in odor and laboratory urine, nephritis.
Adverse effects in children.
Side effects that were registered in children are similar to those in adults. The most frequent adverse events were diarrhea, taste change, rash and vomiting. In addition, the development of viral infections, fever, constipation, hepatomegaly, pancreatitis, dry skin, decreased hemoglobin, changes in mineral metabolism (levels of potassium, sodium and calcium), hyperbilirubinemia, and a decrease in the number of platelets were recorded.