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Multiple myeloma continues to be an incurable illness despite the invention of immunomodulatory agents, such as lenalidomide/thalidomide and the proteasome inhibitor bortezomib that managed to improve the conditions of patients with recently diagnosed and/or refractory disorders. Nevertheless, patients relapsing after the therapy with these substances or are resistant to them represent an unmet demand and emphasize the need for the development of innovative anti-myeloma drugs. Pomalidomide 4 mg represents an immunomodulatory drug, structurally linked to thalidomide, with increased anti-cancer, anti-inflammatory and antiangiogenic properties, which demonstrates a high anti-myeloma activity in the laboratory and in vivo. Pomalidomide has proven highly effective in patients resistant to lenalidomide and bortezomib.
You should take the drug orally (irrespective of the mealtime), generally once a day for 3 weeks; after that, you should stop the treatment for a week. This is called “treatment cycle”. Keep taking Pomalidomide 4 mg according to your doctor’s prescription.
Swallow the pills whole with a full glass of liquid. Avoid breaking or chewing the pills. If the medication contacts your skin, wash it thoroughly with soap and water.
The dose depends on your disease, reaction to the therapy, laboratory findings and other drugs you’re currently using. Inform your physician about all the drugs you take (prescription/over-the-counter medications and herbal supplements).
Take Pomalidomide 4 mg on a regular basis to achieve the best effects. Try to take the drug at the same time every day to prevent skipping the dose.
Pomalidomide 4 mg is can be purchased from a certified drug store under a specific program known as “ Pomalidomide REMS”. Your physician needs to be registered in the program to be able to prescribe the medication. You should be registered in the program and sign the papers indicating that you realize the risks of this drug and that you agree to use contraceptives.
How often must the patients be monitored?
Laboratory tests should be checked before the therapy, once a week during the first 2 months of therapy with Pomalidomide 4 mg, and then every 14 days for about 2 months, then once a month. Bone marrow biopsies (samples) should be made before beginning the therapy, after 3 months, after 4 months, then every 6 months thereafter and when illness exacerbates.