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Contraindications of Tygacil 100mg.
Hypersensitivity to the active substance or to any of the excipients of the remedy, as well as to other tetracycline remedies.
Dosage and Administration of Tygacil 100mg.
The initial recommended dose is 100 mg, then apply 50 mg every 12 hours for 5-14 days. The duration of treatment should depend on the severity of the disease, the localization of the infection and the clinical response of the patient. Tygacil 100mg is administered intravenously for 30-60 minutes. The prepared solution should be used immediately.
Adverse Reactions of Tygacil 100mg.
Most commonly, such transient side effects as nausea (20%) and vomiting (14%), abscesses, infections, pneumonia, lengthening of
activated partial thromboplastin time, lengthening of prothrombin time, hypoglycemia, dizziness, phlebitis, diarrhea, abdominal pain, dyspepsia, anorexia, elevation of the level aspartate aminotransferase, alanine aminotransferase , hyperbilirubinemia, pruritus, rash, headache, increased levels of amylase, and urea nitrogen in the blood. Pseudomembranous colitis can arise from a minor degree of severity to a life-threatening condition. Excessive growth of microorganisms insensitive to antibiotics, including fungi. It is not recommended to use Tygacil 100mg for children.
Features of the application of Tygacil 100mg.
In the application of tigecycline, the development of anaphylactic / anaphylactoid reactions has been reported, which are potentially life-threatening; cases of liver damage, predominantly of the cholestatic type, including cases of hepatic insufficiency with a lethal outcome, acute pancreatitis, incl. heavy. To monitor the condition of patients who are using tigecycline along with anticoagulants, a test should be used to determine prothrombin time or another similar test to determine the coagulation parameters.
Interaction with other remedies and other types of interactions.
If tigecycline is used simultaneously with anticoagulants, patients should be closely monitored using appropriate tests to determine coagulation. Warfarin does not affect the pharmacokinetic profile of tigecycline. It is expected that the inhibition or inducers of the CYP450 isoforms do not affect the clearance of tigecycline. With the simultaneous use of tigecycline with digoxin, there is no need to adjust the dose. In vitro studies, there was no antagonism between tigecycline and antibiotics of other classes, which are often used in therapy. Simultaneous use of antibiotics with oral contraceptives can reduce the effectiveness of contraceptives.
Pharmacological properties of Tygacil 100mg.
Tigecycline, an antibiotic of the glycylcycline line, inhibits protein translation in bacteria by attachment to the 30S ribosomal subunit and blocking the entry of the amino-acyl-tRNA molecules into the ribosome A site, which prevents the inclusion of amino acid residues in the expandable peptide chains. Generally consider that tigecycline is characterized by bacteriostatic action.