Imatinib 400mg

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Composition of Imatinib 400 mg.

One Imatinib 400 mg tablet coated with an envelope may contain 50 mg of Imatinib 400 mg (used in the form of mesylate) and 65.2 mg of low-substituted giprolose, 0.285 mg of povidone, 21 mg of sodium carboxymethyl starch, 1.9 mg of colloidal silica, 1,035 mg of stearate magnesium. The components of the shell are 6.84 mg of yellow opadry, 0.36 mg of red opadry.
One tablet can contain 100 or 400 mg of Imatinib 400 mg (used in the form of mesylate) and anhydrous anhydrous lactose, croscarmellose sodium, povidone K30, talc, magnesium stearate and crospovidone.

Indications for using of Imatinib 400 mg.

Treatment with Imatinib 400 mg is prescribed for chronic myelogenous leukemia, as well as during blast crisis and in the phase of exacerbation. Most often the remedy is used in case of unsuccessful treatment with Interferon Alpha.
The remedy is also used in adults with inoperable and / or metastatic gastrointestinal tumors (GIST). Conduct adjuvant therapy after resection of GIST.

Contraindications of Imatinib 400 mg.

Presence of hypersensitivity reactions to any of the components of Imatinib 400 mg.
There is no data on safety and efficacy in children under 3 years of age.
With caution, it is necessary to apply the remedy to patients with impaired liver function, since it is possible to enhance the effect of this antitumor agent.

Side effects of Imatinib 400 mg.

rash;
myalgia, muscle spasm;
diarrhea, nausea and vomiting;
peripheral edema (usually with diuretics or with a lower dose of Imatinib 400 mg).
Imatinib 400 mg, instructions for using (method and dosage)
The remedy is recommended to be taken orally once a day – during a full meal, with enough water – about 200 ml. Therapy is carried out long before reaching hematological remission or maintaining clinical.

Therapy at the stage of remission.

The recommended daily intake for adults is 400 mg. If for 3 months. the disease progresses or the hematological effect is insufficient – the daily dose can be increased to 600 mg.
An exacerbation or blast crisis.
The recommended daily intake for adults is 400 mg. If there is no improvement and no pronounced adverse reactions are observed, the patient is transferred to a large dose of 800 mg, which is divided into 2 divided doses during the day.

Calculation of dosage of Imatinib 400 mg for children.
Calculation of the dose is carried out based on the surface area of the body, and is measured in mg / m2. The maximum daily dose should not exceed the equivalent standard daily for adults (from 400 mg to 600 mg).

Overdose of Imatinib 400 mg.

The experience of using Imatinib 400 mg in doses over 600 mg is limited. Therapy of 1200 mg for 6 days in some cases led to an increase in the concentration of serum creatinine, bilirubin, hepatic transaminases, the development of ascites. After the suspension of treatment, all indicators returned to the baseline level after 1 week. When using a dose of 1600 mg / day for 6 days in a row, the patient experienced severe muscle cramps, which stopped when the remedy was withdrawn.

Treatment.

In case of an overdose, appropriate symptomatic therapy is carried out and the patient is placed under follow-up.

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